刘江俊;刘忠强;田少奇;王远贺;孙康;

• 1:青岛大学医学院
• 2:青岛大学附属医院

摘要(Abstract)：

[目的]探讨不同剂量氨甲环酸对减少单侧全膝关节置换术后出血的疗效及安全性。[方法]选取2012年7月~2013年7月因骨性关节炎行单侧全膝关节置换的142例患者进行研究。采用随机数表法将患者分为三组,A组48例,松止血带前30 min给予100 ml 5%葡萄糖注射液静脉点滴;B组48例,松止血带前30 min将氨甲环酸0.75 g稀释于100 ml 5%葡萄糖注射液后静脉点滴;C组46例,松止血带前30 min将氨甲环酸1.5 g稀释于100 ml 5%葡萄糖注射液后静脉点滴。比较患者术后总出血量、显性出血、隐性出血及部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶原国际标准化比值(PT-INR)、D二聚体等方面。同时三组患者术后第5 d行下肢血管彩超,均随访3个月,观察是否出现下肢深静脉血栓。[结果]三组患者术后总出血量、显性出血量、术后引流量、术后3 d输血人数及术后D-二聚体两两比较,差异有统计学意义(P<0.01)。三组患者术中出血量、术后隐性出血量、术后3 h PT、APTT、PT-INR比较差异无统计学意义(P>0.05),三组患者血栓栓塞事件差别无统计学意义。[结论]单侧全膝关节置换术松止血带前30 min应用氨甲环酸不能明显减少患者术后的隐性出血,但能够显著减少术后总出血量、显性出血量及术后异体血输血人数,剂量为1.5 g时更为有效,并且不会增加患者术后血栓形成风险。

关键词(KeyWords)： 氨甲环酸;关节成形术;膝关节;出血;血栓

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 刘江俊;刘忠强;田少奇;王远贺;孙康;

Email:

DOI:

参考文献(References)：

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