廖子黎;斯海波;沈彬;

• 1:四川大学华西医院骨科

摘要(Abstract)：

静脉血栓栓塞症(VTE)是骨科大手术,尤其是髋膝关节置换后发生率较高的并发症,也是患者围手术期死亡的重要原因之一。VTE主要有两种临床表现形式,一是深静脉血栓形成(DVT),二是肺动脉血栓栓塞症(PTE)。VTE发生的危险因素是多方面、多层次的。炎症相关因子、同型半胱氨酸等在DVT发生发展中起重要作用。在分子调控层面,多个调节因子如由内皮细胞表达的微小RNA (miRNA)和mRNA、沉默信息调节因子1等均参与了DVT发生。临床上已采用检测指标,如D-二聚体水平、炎性细胞比值等,较好预测DVT发生。在重视三大病因的基础上,对新的危险因素予以适当的评估干预将有助于指导临床VTE的诊治预防及改善患者预后。

关键词(KeyWords)： 全髋关节置换;全膝关节置换;深静脉血栓;危险因素;预防

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目（编号：81672219、81802210、81974347）;; 四川省科技厅重点项目（编号：2018SZ0223、2018SZ0250）

作者(Author): 廖子黎;斯海波;沈彬;

Email:

DOI:

参考文献(References)：

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