调控软骨生成和软骨内骨化的转录因子及其相关机制研究进展
吕学敏,杨庆铭,邓廉夫
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作者(Author): 吕学敏,杨庆铭,邓廉夫
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参考文献(References)：
- [1] GerardKarsenty,ErwinF .Wagner.Reachingageneticandmolec ularunderstandingofskeletaldevelopment[J].DevCell,2002,2:389～406.
- [2] vandeWeteringM ,CleversH .Sequence specificinteractionoftheHMGboxproteinsTCF 1andsryoccurswithintheminorgrooveofaWatsonCrickdoublehelix[J].EmboJ,1992,11:3039～3044.
- [3] WegnerM .Fromheadtotoes:themultiplefacetsofSox proteins[J].NucleicAcidsRes,1999,27:1409～1420.
- [4] FosterJW ,DominguezsteglichMA ,GuioliS ,etal.CampomelicdysplasiaandautosomalsexreversalcausedbymutationsinanSry relatedgene[J].Nature,1994,372:525～530.
- [5] WrightE ,HargraveMR ,ChristiansenJ ,etal.TheSry relatedgeneSox9isexpressedduringchondrogenesisinmouseembryos[J].NatGenet,1995,9:15～20.
- [6] BellDM ,LeungKKH ,WheatleySC ,etal.Sox9directlyregulatesthetypeⅡcollagengene[J].NatGenet,1997,16:174～178.
- [7] ChrisHealy,DafeUwanogho,PaulT .Sharpe.RegulationandroleofSox9incartilageformation[J].DevDyn,1999,215:69～78.
- [8] HaradaS ,NakayamaK ,HirokoO ,etal.ActivationofSox9re sponseelementbyconstitutivelyactivetypeIBMPreceptorsviaaSMADsdependentPathway[J].Bone,1998,23:S239.
- [9] MurakamiS ,KanM ,McKeehanWL ,etal.Up regulationofthechondrogenicSox9genebyfibroblastgrowthfactorsismediatedbythemitogen activatedproteinkinasepathway[J].Proc.Natl.A cad.Sci.USA ,2000,97:1113～1118.
- [10]HuangW ,ChungUI ,KronenbergHM ,etal.ThechongdrogenictranscriptionfactorSox9isatargetofsignalingbyendochondralbones[J].ProcNatlAcadSciUSA ,2001,98:160～165.
- [11]BenoitdeCrombrugghe,VeroniqueLefebvre,KazuhisaNakashima.Regulatorymechanismsinthepathwaysofcartilageandboneforma tion[J].CurrOpininCellBiol,2001,13:721～727.
- [12]SmitsP ,LiP ,MandelJ ,etal.ThetranscriptionfactorL Sox5andSox6areessentialforcartilageformation[J].DevCell,2001,1(2):277～290.
- [13]PapaioannouV .E .T boxfamilyreunion[J].TrendsGenet,1997,13:212～213.
- [14]KispertA .TheBrachyuryprotein:aT domaintranscriptionfactor[J].SeminDevBiol,1995,6:395～403.
- [15]AndreaHoffmann,StefanCzichos,ChristianKaps,etal.TheT boxtranscriptionfactorBrachyurymediatescartilagedevelopmentinmesenchymalstemcelllineC3H10T1/2[J].JCellSci,2002,115:769～781.
- [16]PfeiferOhissonS ,RydnertJ,GoustinAS ,etal.Cell type specificpatternofmycprotooncogeneexpressionindevelopinghumanem bryos[J].ProcNatlAcadSciUSA ,1985,82:5050～5054.
- [17]DesbiensX ,QuevaC ,JaffredoT ,etal.Therelationshipbetweencellproliferationandthetranscriptionofthenuclearoncogenesc myc,c mybandc ets1duringfeathermorphogenesisinthechickembryo[J].Development,1991,111:699～713.
- [18]M .ElisaPiedra,M .DoloresDelgado,MariaA .Ros,etal.cMycoverexpressionincreasescellsizeandimpairscartilagedifferentiationduringchicklimbdevelopment[J].CellGrowthDiff,2002,13:185～193.
- [19]ItoY .Molecularbasisoftissue specific geneexpressionmediatedbytheruntdomaintranscriptionfactorPEBP2/CBF [J].GenesCells,1999,4:685～696.
- [20]AkiraYamaguchi,ToshihisaKomori,TatsuoSuda.Regulationofosteoblastdifferentiationmediatedbybonemorphogeneticproteins,Hedgehogs,andCbfal[J].EndocineReviews,2000,21:393～411.
- [21]ShuTakeda,JeanPierreBonnamy,MichaeiJ.Owen,etal.Con tinuousexpressionofCbfalinnonhypertrophicchondrocytesuncov ersitssbilitytoinducehypertrophicchondrocytediffermtiationandpartiallyrescuesCbfal deficientmice[J].GenesDev,2001,15:467～481.
- [22]ChisatoUeta,MasahiroIwamoto,NaokoKanatani,etal.SkeletalmalformationscausedbyoverexpressionofCbfaloritsdominantneg ativeforminchondrocytes[J].JCellBiol,2001,153:87～99.
- [23]KomoriT ,YagiH ,NomuraS ,etal.TargeteddisruptionofCbfalresultsinacompletelackofboneformationowingtomaturationalarrestofosteoblasts[J].Cell,1997,89:755～764.
- [24]PhoebeSL ,GioviGrassoKnight,MarinaD ,etal.SmadRunxin teractionsduringchondrocytematuration[J].JBoneJointSurgery(Am),2001,83:15～22.
- [25]KazuhisaNakashia,XinZhou,GaryKunkel,etal.Thenovelzincfinger containingtranscriptionfactorOsterixisrequiredforos teoblastdifferentiationandboneformation[J].Cell,2002,108:17～29.
- [26]WasylykB ,HagmanJ,GutierrezHartmannA .Etstranscriptionfactors:nucleareffectorsoftheRasMAP kinasesignalingpathway[J].TrendsBiochemSciences,1998,23:213～216.
- [27]PrasadDDK ,VN .Rao,L .Lee,etal.Differntiall