组织工程骨软骨复合组织构建研究进展Research progress of construction of tissue engineered osteochondral composite tissue
赵家宁;徐宝山;杨强;
摘要(Abstract):
本文综述了近几年骨软骨组织工程研究进展。查阅近几年有关骨软骨组织工程的文献,于支架材料、信号因子、种子细胞及制备技术等方面加以总结分析。骨软骨组织工程根据仿生学理论与方法完成组织替代物的制备并对损伤或有缺陷组织进行修复,可有效恢复受损骨软骨组织的结构功能与力学特性,是一种具有长远意义的综合交叉学科。目前,骨软骨组织工程策略针对骨软骨损伤取得了一定的成果,但仍需进一步发展,最终为骨软骨损伤提供一种成熟的临床治疗方法。
关键词(KeyWords): 骨软骨组织工程;骨软骨损伤;骨软骨支架
基金项目(Foundation): 国家自然科学基金课题资助(编号:31000432,31300798,81272046);; 天津市卫生局科技基金(项目编号:2013KR16)
作者(Author): 赵家宁;徐宝山;杨强;
Email:
DOI:
参考文献(References):
- [1]Mc Nickle AG,Provencher MT,Cole BJ.Overview of existing cartilage repair technology[J].Sports Med Arthrosc,2008,4:196-201.
- [2]Ye K,Di Bella C,Myers DE,et al.The osteochondral dilemma:review of current management and future trends[J].ANZ J Surg,2014,4:211-217.
- [3]杨强,彭江,卢世璧,等.组织工程骨软骨复合体的研究进展及展望[J].中国矫形外科杂志,2008,8:606-609.
- [4]Panseri S,Russo A,Cunha C,et al.Osteochondral tissue engineering approaches for articular cartilage and subchondral bone regeneration[J].Knee Surg Sports Traumatol Arthrosc,2012,6:1182-1191.
- [5]Nukavarapu SP,Dorcemus DL.Osteochondral tissue engineering:current strategies and challenges[J].Biotechnol Adv,2013,5:706-721.
- [6]Hoemann CD,Lafantaisie-Favreau CH,Lascau-Coman V,et al.The cartilage-bone interface[J].J Knee Surg,2012,2:85-97.
- [7]Castro NJ,Hacking SA,Zhang LG.Recent progress in interfacial tissue engineering approaches for osteochondral defects[J].Ann Biomed Eng,2012,8:1628-1640.
- [8]Burr DB.Anatomy and physiology of the mineralized tissues:role in the pathogenesis of osteoarthrosis[J].Osteoarthritis Cartilage,2004,12:20-30.
- [9]Responte DJ,Natoli RM,Athanasiou KA.Collagens of articular cartilage:atructure,function,and importance in tissue engineering[J].9512Crit Rev Biomed Eng,2007,5:363-411.
- [10]Mente PL,Lewis JL.Elastic modulus of calcified cartilage is an order of magnitude less than that of subchondral bone[J].J Orthop Res,1994,5:637-647.
- [11]Schinagl RM,Gurskis D,Chen AC,et al.Depth-dependent confined compression modulus of fullt Thickness bovine articular cartilage[J].J Orthop Res,1997,4:499-506.
- [12]Zhang L,Hu J,Athanasiou KA.The role of tissue engineering in articular cartilage repair and regeneration[J].Crit Rev Biomed Eng,2009,1-2:1-57.
- [13]Hutmacher DW.Scaffolds in tissue engineering bone and cartilage[J].Biomaterials,2000,24:2529-2543.
- [14]王永成,袁雪凌,汪爱媛,等.膝关节骨软骨损伤的治疗策略[J].中国修复重建外科杂志,2014,1:110-115.
- [15]Oldinski RA,Ruckh TT,Staiger MP,et al.Dynamic mechanical analysis and biomineralization of hyaluronan-polyethylene copolymers for potential use in osteochondral defect repair[J].Acta Biomater,2011,3:1184-1191.
- [16]Khanarian NT,Haney NM,Burga RA,et al.A functional agarosehydroxyapatite scaffold for osteochondral interface regeneration[J].Biomaterials,2012,21:5247-5258.
- [17]FilováE,RampichováM,Litvinec A,et al.A Cell-free nanofiber composite scaffold regenerated osteochondral defects in miniature Pigs[J].Int J Pharm,2013,1-2:139-149.
- [18]Xie X,Wang Y,Zhao C,et al.Comparative evaluation of MSCs from bone marrow and adipose tissue seeded in PRP-Derived scaffold for cartilage regeneration[J].Biomaterials,2012,29:7008-7018.
- [19]Schwarz S,Koerber L,Elsaesser AF,et al.Decellularized cartilage matrix as a novel biomatrix for cartilage tissue-engineering applications[J].Tissue Eng Part A,2012,21-22:2195-2209.
- [20]Chen J,Chen H,Li P,et al.Simultaneous regeneration of articular cartilage and subchondral bone in vivo using MSCs induced by a spatially controlled gene delivery system in bilayered integrated scaffolds[J].Biomaterials,2011,21:4793-4805.
- [21]Yang Q,Peng J,Lu SB,et al.Evaluation of an extracellular matrixderived acellular biphasic scaffold/cell construct in the repair of a large articular high-load-bearing osteochondral defect in a canine model[J].Chin Med J(Engl),2011,23:3930-3938.
- [22]Schleicher I,Lips KS,Sommer U,et al.Allogenous bone with collagen for repair of deep osteochondral defects[J].J Surg Res,2013,2:667-675.
- [23]Schek RM,Taboas JM,Segvich SJ,et al.Engineered osteochondral grafts using biphasic composite solid free-form fabricated scaffolds[J].Tissue Eng,2004,9-10:1376-1385.
- [24]Jiang J,Tang A,Ateshian GA,et al.Bioactive stratified polymer ceramic-hydrogel scaffold for integrative osteochondral repair[J].Ann Biomed Eng,2010,6:2183-2196.
- [25]Levingstone TJ,Matsiko A,Dickson GR,et al.A biomimetic multilayered collagen-based scaffold for osteochondral repair[J].Acta Biomater,2014,5:1996-2004.
- [26]Mohan N,Dormer NH,Caldwell KL,et al.Continuous gradients of material composition and growth factors for effective regeneration of the osteochondral interface[J].Tissue Eng Part A,2011,21-22:2845-2855.
- [27]Tang G,Zhang H,Zhao Y,et al.Preparation of PLGA scaffolds with graded pores by using a gelatin-microsphere template as porogen[J].J Biomater Sci Polym Ed,2011.DMID:22137329.
- [28]Dormer NH,Singh M,Zhao L,et al.Osteochondral interface regeneration of the rabbit Knee with macroscopic gradients of bioactive signals[J].J Biomed Mater Res A,2012,1:162-170.
- [29]Zhang W,Chen J,Tao J,et al.The rromotion of osteochondral repair by combined intra-articular injection of parathyroid hormone-related protein and implantation of a bi-layer collagen-silk scaffold[J].Biomaterials,2013,25:6046-6057.
- [30]Li X,Su G,Wang J,et al.Exogenous b FGF promotes articular cartilage repair via up-regulation of multiple growth factors[J].Osteoarthritis Cartilage,2013,10:1567-1575.
- [31]Liu H,Peng H,Wu Y,et al.The promotion of bone regeneration by nanofibrous hydroxyapatite/chitosan scaffolds by effects on integrinBMP/Smad signaling pathway in BMSCs[J].Biomaterials,2013,18:4404-4417.
- [32]Pulkkinen HJ,Tiitu V,Valonen P,et al.Repair of osteochondral defects with recombinant human type II collagen gel and autologous chondrocytes in rabbit[J].Osteoarthritis Cartilage,2013,3:481-490.
- [33]Marlovits S,Zeller P,Singer P,et al.Cartilage repair:generations of autologous chondrocyte transplantation[J].Eur J Radiol,2006,1:24-31.
- [34]Wang L,Zhao L,Detamore MS.Human umbilical cord mesenchymal stromal cells in a sandwich approach for osteochondral tissue engineering[J].J Tissue Eng Regen Med,2011,9:712-721.
- [35]Suzuki S,Muneta T,Tsuji K,et al.Properties and usefulness of aggregates of synovial mesenchymal stem cells as a source for cartilage regeneration[J].Arthritis Res Ther,2012,3:136.
- [36]Rodrigues MT,Lee SJ,Gomes ME,et al.Bilayered constructs aimed at osteochondral strategies:the influence of medium supplements in the osteogenic and chondrogenic differentiation of amniotic fluid-derived stem cells[J].Acta Biomater,2012,7:2795-2806.
- [37]Chang NJ,Lam CF,Lin CC,et al.Transplantation of autologous endothelial progenitor cells in porous PLGA scaffolds create a microenvironment for the regeneration of hyaline cartilage in rabbits[J],Osteoarthritis Cartilage,2013,10:1613-1622.
- [38]Lee JY,Choi B,Wu B,et al.Customized biomimetic scaffolds created by indirect three-dimensional printing for tissue engineering[J].Biofabrication,2013,4:045003.
- [39]Ding C,Qiao Z,Jiang W,et al.Regeneration of a goat femoral head using a tissue-specific,biphasic scaffold fabricated with CAD/CAM technology[J].Biomaterials,2013,28:6706-6716.