王锋;吴小涛;陈辉;王运涛;

• 1:东南大学附属中大医院骨科

摘要(Abstract)：

[目的]报道1例股骨下段孤立性浆细胞瘤的诊治并综述相关文献。[方法]查阅有关骨内孤立性浆细胞瘤的文献,结合1例发生于股骨下段孤立性浆细胞瘤的诊治过程,从发病、诊断、治疗、预后等方面认识该罕见病。[结果]孤立性浆细胞是一种以单克隆浆细胞失控增殖为特征的少见肿瘤;活检病理及免疫细胞化学检测确诊后,局部彻底切除和放疗是当前较有效的治疗方案;该病的预后和M蛋白水平及持续时间、原发瘤大小、有无复发等因素有关。[结论]孤立性浆细胞瘤是一种易向多发性骨髓瘤恶变的罕见肿瘤,及时的确诊、手术、放疗以及长期随访对改善预后很重要。

关键词(KeyWords)： 骨肿瘤;浆细胞瘤;病例报告

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 王锋;吴小涛;陈辉;王运涛;

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参考文献(References)：

• [1]白元松,孙步彤,张秀梅.孤立性浆细胞瘤21例[J].中国肿瘤临床,2008,6:319-320.
• [2]夏贤良,张德钧.骨的孤立性浆细胞瘤[J].中华骨科杂志,1983,3:211-213.
• [3]Soutar R,Lucraft H,Jackson G,et al.Guidelines on the dagnosis andmanagement of solitary plasmacytoma of bone and solitary extramedul-lary plasmacytoma[J].Br J Haematol,2004,6:717-726.
• [4]燕太强,郭卫,汤小东,等.骨单发性浆细胞瘤的诊治[J].中华外科杂志,2003,10:749-752.
• [5]Mayr NA,Wen BC,Hussey DH,et al.The role of radiation therapy inthe treatment of solitary plasmacytomas[J].Radiother Oncol,1990,4:293-303.
• [6]Liebross RH,Ha GS,Cox JD,et al.Solitary bone plasmacytoma:out-come and prognostic factors following radiotherapy[J].Oncol BiolPhys,1998,5:1063-1067.
• [7]杨迪生,范顺武,陶惠明,等.骨的孤立性浆细胞瘤和髓外浆细胞瘤[J].中华肿瘤杂志,1996,1:41-44.
• [8]Burt M,Karpeh M,Ukoha O,et al.Medical tumors of the chest wallsolitary plasmacytoma and Ewing sarcoma[J].Theraco Cardiovas Su-ry,1993,1:89-96.
• [9]Tsang RW,Gospodarowicz MK,Pintilie M,et al.Solitary plasmacytomatreated with radiotherapy:impact of tumour size on outcome[J].Int JRadiat Oncol Biol Phys,2001,50:1 13-120.
• [10]Wilder RB,Ha CS,Cox JD,et al.Persistence of myeloma protein formore than one year after radiotherapy is an adverse prognostic factor insolitary plasmacytoma of bone[J].Cancer,2002,94:1532-1537.
• [11]Mayer JE,Schulz MD.“Solitary”myeloma of bone:a reviewof12 cases[J].Cancer,1974,2:438-440.
• [12]Bataille R,Sany J.Solitary myeloma:clinical and prognostic features ofa review of 114 cases[J].Cancer,1981,3:845-851.