路玉峰;郭万首;程立明;

• 1:中日友好医院骨关节外科
• 2:北京协和医学院研究生院

摘要(Abstract)：

大剂量糖皮质激素的使用是我国非创伤性股骨头坏死的主要原因,其确切的发病机制至今仍不明确,近期国内外研究认为股骨头内部骨微血管内皮细胞的损伤可能在股骨头内骨细胞及骨髓坏死的过程中扮演着重要的作用。微血管内皮细胞损伤不仅可以造成局部的凝血活性增高,形成微血栓,局部血管闭塞,导致支配区域股骨头坏死,而且损伤的微血管内皮细胞产生了大量的活性氧,减少了舒血管物质的合成,进一步加剧了内皮细胞本身的损伤及骨细胞、骨髓坏死。

关键词(KeyWords)： 糖皮质激素;股骨头;内皮细胞

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(编号:81273972)

作者(Author): 路玉峰;郭万首;程立明;

Email:

DOI:

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