活化蛋白激酶在骨肉瘤中的表达及其意义Expression and significance of MAPK in osteosarcoma
雷会宁;蔡郑东;郑建明;李国东;郑龙坡;
摘要(Abstract)：
[目的]探讨细胞分裂素活化蛋白激酶(MAPK)中细胞外信号调节蛋白激酶(ERK)、c-jun氨基末端激酶(JNK)、P38三条通路在骨肉瘤发生中的作用。[方法]用免疫组织化学技术EnV isionTM法检测48例骨肉瘤标本及25例成骨性良性肿瘤标本中ERK、JNK、P38蛋白的表达,并比较他们的差异。[结果]ERK、JNK、P38三种蛋白在骨肉瘤组的阳性率分别为83.3%(40/48),72.9%(35/48)和85.4%(41/48),在成骨性良性肿瘤组中的阳性率分别为16.0%(4/25),12.0%(3/25)和20.0%(5/25),骨肉瘤组织中ERK、JNK、P38蛋白阳性率及阳性强度均明显高于成骨性良性肿瘤(P<0.01)。[结论]MAPK中ERK、JNK、P38三条通路在骨肉瘤发生中均发挥了重要作用,用免疫组织化学方法检测MAPK,可为临床骨肉瘤与良性骨肿瘤的诊断与鉴别诊断提供参考指标。
关键词(KeyWords)： 细胞分裂素活化蛋白激酶;免疫组织化学;骨肉瘤
基金项目(Foundation): 国家自然科学基金资助项目(No.30170955)
作者(Author): 雷会宁;蔡郑东;郑建明;李国东;郑龙坡;
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DOI:
参考文献(References)：
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