成楠;刘欢;周跃;

• 1:第三军医大学新桥医院骨科

摘要(Abstract)：

表观遗传学机制包括DNA甲基化,组蛋白修饰和microRNA,表观遗传学调控基因表达改变持久、可遗传并且不涉及DNA序列改变,各个领域中对于表观遗传学机制的研究和应用已经成为新的热点。软骨组织再生医学领域中的表观遗传学机制研究,为干细胞向软骨细胞分化以及软骨细胞终末分化提供了多种调控方式。但是,目前的研究主要是在体外常氧条件下,软骨组织工程细胞最终将应用于体内低氧环境中,低氧环境与表观遗传学机制之间相互影响将是研究者们需要关注的重点。本综述意在收集近年来干细胞成软骨分化中表观遗传学调控的研究成果以及各个研究领域中低氧环境与表观遗传学机制间的相互影响,希望能够为软骨组织工程细胞体内应用研究提供新的思路。

关键词(KeyWords)： 表观遗传学;间充质干细胞;软骨分化;软骨肥大;低氧;DNA甲基化;组蛋白修饰;microRNA

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 成楠;刘欢;周跃;

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DOI:

参考文献(References)：

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