黄进成;刘曦明;蔡贤华;Edward M.Schwarz;Chao Xie;

• 1:中国人民解放军总医院骨科
• 2:三峡大学第二人民医院
• 3:罗彻斯特大学医学院骨科研究中心

摘要(Abstract)：

在感染性骨缺损的治疗过程中对感染控制与骨重建是制约临床疗效的两大难题。尽管Ilizarov骨搬移技术、带血管的自体骨移植技术、Papineau技术等能够成功修复骨缺损,但仍存在明显的不足。Masquelet骨重建技术虽在其他国家报道较多,但国内尚未予以足够重视。本文综述近年来Masquelet技术治疗感染性骨缺损的相关文献,旨在提高对其疗效的认识及重视。

关键词(KeyWords)： 骨缺损;感染;Masquelet技术;预防;治疗

Abstract:

Keywords:

基金项目(Foundation): 湖北省卫生计生西医类一般项目(编号:WJ2015MB119)

作者(Author): 黄进成;刘曦明;蔡贤华;Edward M.Schwarz;Chao Xie;

Email:

DOI:

参考文献(References)：

• [1]Mario R,Sergio F,Alessandro F,et al.Masquelet technique for the treatment of a severe acute tibial bone loss[J].Injury,2014,45(1):111-115.
• [2]Masquelet AC,Fitoussi F,Begue T,et al.Reconstruction of the long bones by the induced membrane and spongy auto graft[J].Ann Chir Plast Esthet,2000,45(3):346-353.
• [3]Karargyris O,Polyzois VD,Karabinas P,et al.Papineau debridement,Ilizarov bone transport and negative-pressure wound closure for septic bone defects of the tibia[J].Eur J Orthop Surg Traumatol,2014,24(6):1013-1017.
• [4]Zhao X.The difficulties and challenges of the diagnosis and treatment of extremity trauma[J].Chinese J Trauma,2015,31(4):289-293.
• [5]Zhang BZ,Hua YH,Yu B,et al.Recombinant ESAT-6-Like Proteins Provoke Protective Immune Responses against Invasive Staphylococcus aureus Disease in a Murine Model[J].Infection and Immunity,2015,83(1):339-345.
• [6]Henrich D,Seebach C,Nau C,et al.Establishment and characterization of the Masquelet induced membrane technique in a rat femur critical-sized defect model[J].J Tissue Eng Regen Med,2013,8(10):1816-1826.
• [7]Gruber HE,Gettys FK,Montijo HE,et al.Genomewide molecular and biologic characterization of biomembrane formation adjacent to a methacrylate spacer in the rat femoral segmental defect model[J].J Orthop Trauma,2013,27(5):290-297.
• [8]Gouron R,Petit L,Boudot C,et al.Osteoclasts and their precursors are present in the induced-membrane during bone reconstruction using the Masquelet technique[J].J Tissue Eng Regen Med,2014,12(10):1911-1921.
• [9]Zhao X,Yu SP,Fu JS,et al.Clinical observation of Masquelet technique in treatment ofosteomyelitis bone defects of long bones:report of 25 cases[J].J Third Mil Med Univ,2014,36(15):1630-1634.
• [10]Gouron R.Surgical technique and indications of the induced membrane procedure in children[J].Orthop Traumatol Surg Res,2016,102(1):133-139.
• [11]Ma CH,Wu CH,Tu YK,et a1.Metaphyseal locking plate as a definitive external fixator for treating open tibial fractures-clinical outcome and a finite element study[J].Injury,2013,44(8):1097-1101.
• [12]Aho OM,Lehenkari P,Ristiniemi J,et al.The mechanism of action of induced membranes in bone repair[J].J Bone Joint Surg Am,2013,95(7):597-604.
• [13]Xie Z,Xiaohua W,Fuda W,et al.Induction of granulation tissue for the secretion of growth factors and the promotion of bone defect repair[J].Ournal Orthop Surg Res,2015,10(1):1-8.
• [14]Mc Conoughey SJ,Wiseman J,Stoodley P,et al.Comparing PMMAand calcium sulfate as carriers for the local delivery of antibiotics to infected surgical sites[J].J Biomed Mater Res B Appl Biomater,2015,103(4):870-877.
• [15]Beenken KE,Smith JK,Skinner RA,et al.Chitosan coating to enhance the therapeutic efficacy of calcium sulfate-based antibiotic therapy in the treatment of chronic osteomyelitis[J].J Biomater Appl,2014,4:514-523.
• [16]Bhattacharya R,Kundu B,Nandi SK,et al.Systematic approach to treat chronic osteomyelitis through localized drug delivery system:bench to bed side[J].Mater Sci Eng C Mater Biol Appl,2013,33(7):3986-3993.
• [17]Cui X,Zhao C,Gu Y,et al.A novel injectable borate bioactive glass cement for local delivery of vancomycin to cure osteomyelitis and regenerate bone[J].J Mater Sci Mater Med,2014,25(3):733-745.
• [18]Christoph N,Caroline S,Alexander T,et al.Alteration of Masquelet’s induced membrane characteristics by different kinds of antibiotic enriched bone cement in a critical size defect model in the rat’s femur[J].Injury,2016,47:325-334.
• [19]Ziran NM,Smith WR.The Ziran wrap:reconstruction of criticalsized long bone defects using a fascial autograft and reamer-irrigator-aspirator autograft[J].Patient Saf Surg,2014,8(1):1-15.
• [20]Hesse E,Kluge G,Atfi A,et a1.Repair of a segmental long bone defect in human by implantation of a novel muhiple disc graft[J].Bone,2010,46(5):1457-1463.
• [21]Liu XM,Wang F,Wang GD,et al.Cellular compatibility between demineralized bone matrix decorated with poly-L-lysine and bone marrow stem cells[J].Chinese J Orthop Trauma,2015,17(11):982-988.
• [22]Gedbjerg N,La Rosa R,Schwarz EM,et al.Anti-Glucosaminidase Ig G in Sera as a Biomarker of Host Immunity Agains Staphylococcus aureus in Orthopaedic Surgery Patients[J].J Bone Joint Surg,2013,95(171):1-9.
• [23]Varrone JJ,Bentley KLDM,Schwarz EM,et al.Passive immunization with anti-glucosaminidase monoclonal antibodies protects mice from implant-associated osteomyelitis by mediating opsonophagocytosis of Staphylococcus aureus Megaclusters[J].J Orthop Res,2014,32(10):1389-1396.
• [24]Kohei N,Christopher AB,Alexander FR,et al.A Diagnostic serum antibody test for patients with staphylococcus aureus osteomyelitis[J].Clin Orthop,2015,473:2735-2749.
• [25]Yi SQ,Zhang XY,Yang YL,et al.Immunity induced by Staphylococcus aureus surface protein A was protective against lethal challenge of Staphylococcus aureus in BALB/c mice[J].Microbiol Immunol,2012,56:406-410.
• [26]Fabio B,Maria RF,Elisabetta S,et al.Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus[J].PNCS,2015,112(12):3680-3685.